Seroquel seemed to work very well for me. However, the following link is based on research presented May 2007. Quetiapine (Seroquel) has a strong inhibitory effect on ACTH and cortisol secretions among others.
I took Seroquel for several months. I have just been tested as having adrenal insufficiency among other things. My cortisol reading was 2.3 to 0.9 from AM to PM. Kinda low I would say. Normal readings are 10.0 to 1.5 AM to late PM.
I am not a doctor but there is a problem with my anecdotal experiences and the above. Lowered cortisol tends to make make a person UNABLE TO DEAL WITH STRESS. I have been unable to deal with stress since my teenage years and throughout my life since. This made it more difficult to even recover from something like sexual activity. It got worse with age and working long hours. I believe that this condition made me more susceptible to scz and if anything seroquel aggravated it. IMO anyone who has anxiety should get their hormones checked. If you are taking seroquel for anything like scz and have anxiety IMO you should go to a specialist for testing or an alternative practitioner who has the credentials. I did the latter and took saliva/urine tests.
IMO traditional tests for secondary adrenal insufficiency are inadequate for actually detecting the problem EARLY ON. Even in late stages this thing seems to be difficult for doctors to detect. If you have developing symptoms get them treated early with life style changes. Taking street drugs? Good luck!
I will not be taking any shots or substitute hormones or anything like that. That is not the direction I want to take. That is a last resort.